First shoe drops: “Drink Called ‘Cocaine’ Infuriates New York Mayor.” Background here.
Answer to anticipated email: I supose, because OPIUM perfume isn’t targeted at kids.
Answer to a different anticipated email: All I could find was one registration for GOD MADE MARIJUANA for shirts and hats, but I didn’t every single drug name.
Addendum: HT to SB for reminding me of In re Hepperle, 175 USPQ 512 (TTAB 1972), in which ACAPULCO GOLD was held to be registrable for suntan lotion.